Kurt M. Lucin

Biography

Dr. Lucin is interested in how cells of the immune system influence diseases of the nervous system. Before coming to Eastern, Dr. Lucin was a postdoctoral fellow at Stanford University. He earned his Ph.D. in Integrated Biomedical Science with a specialization in neuroscience and immunology from The Ohio State University.

Research Interests

• The role of immune cells in Alzheimer's disease progression

Teaching Interests

• Anatomy
• Physiology
• Histology

Publications

Bieri, G., Lucin, K.M., Villeda, S.A., Czirr E., Wyss-Coray, T. Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Molecular Neurodegeneration. 2018 Dec 29;13(1):68.

Czirr, E., Castello, N., Mosher, K.I., Castellano, J.M., Lucin, K.M., Farina, S., Akassoglou, K., Britschgi, M., Cirrito, J.R., Wyss-Coray, T. Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity. Journal of Experimental Medicine 2017 Apr 3; 214(4):1081-1092.

Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hoffree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain. Molecular Neurodegeneration. 2016 Apr 26;11(1):31.

Lucin, K.M., O’Brien, C.E., Bieri, G., Czirr, E., Abbey, R.J., Mosher, K.I., Spencer, B., Masliah, E., Mastroeni, D., Rogers, J., Wyss-Coray, T. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer’s disease. Neuron 2013 Sep; 79(5): 873–886.

Villeda S.A., Luo J., Mosher K.I., Zou B., Britschgi M., Bieri G., Stan T.M., Fainberg N., Ding Z., Eggel A., Lucin K.M., Czirr E., Park J.S., Couillard-Després S., Aigner L., Li G., Peskind E.R., Kaye J.A., Quinn J.F., Galasko D.R., Xie X.S., Rando T.A., Wyss-Coray T. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011 Aug 31;477(7362):90-4.